Miguel Fernandez de Ullivarri
Research Title: Expression of the antimicrobial killer peptide KP in Lactococcus lactis: its therapeutics properties in models of vulvovaginal candidiasis and its effect on the vaginal microbiome.
Project Summary: This project proposes to develop a model of a less-expensive alternative for the application of the antimicrobial peptide, KP, as a therapeutic agent for vaginal use, compared to the direct administration of the synthetic peptide. The proposal involves the expression of KP in a GRAS microorganism (Lactococcus lactis) and the evaluation of its antifungal properties through an in vivo model of vaginal infection with a pathogenic strain of Candida albicans. Finally, to study its modulatory effects, through next generation sequencing techniques, on the murine vaginal microbiota considering that KP is a potent and broad-spectrum antimicrobial agent.