Research Title: Effect of phage-derived endolysins on gut microbial populations: pathway to developing new therapies against multidrug resistant enteric pathogens.
Project Summary: Bacteriophage endolysins or lysins are highly evolved specific peptidoglycan hydrolases that digest the bacterial cell wall for phage progeny release. In recent years endolysins and their derivatives have emerged as a novel class of antibacterials. The advantages over antibiotics are their specificity for the pathogen without disturbing the normal flora and the low or no chance of bacterial resistance to endolysins. Endolysins have been used successfully in various infectious models to control pathogenic antibiotic resistant bacteria. This project will focus on the effect of phage-derived endolysins on gut microbial populations in order to develop new therapies against multidrug resistant bacterial pathogen.