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APC Forum


Presenters:

Dr Susan Joyce, Lecturer and APC Faculty Investigator: “Microbial-host cross talk through bile acid metabolism”

Dr Martin Hornshaw, Director Scientific Marketing, Metabolon, Inc. (https://www.metabolon.com/): “Dysbiosis, Metabolomics and Disease”

Dysbiosis, when the microbiome becomes imbalanced or deranged, with the normally dominant species now underrepresented and replaced by species which would otherwise be outcompeted, is associated with disease, often in the form of a reduction in microbial diversity. After the observation that a change in the microbiome is associated with disease, what next?

Beebe et al. have proposed that a systematic effort to study the combined host-microbiota metabolome be embedded into microbiome research to fill in the mechanistic gap of understanding between the observation of dysbiosis and associated phenotype. What links the members of a dysbiotic microbial community, step-by-step, to the phenotypic outcome? The answer may well lie in the metabolome.

Studies highlighting key contributions of our commensal microbiota to health and disease continue to mount and while many recent publications associate different bacteria to certain diseases, they have sometimes been criticized for failing to clarify how the microbiome functionally influences disease or promotes health. The language and currency of microbial communities throughout nature are small molecules – metabolites. The systematic application of metabolomics to microbiome research is remarkably feasible and combining metabolomics with traditional microbiome genetic research tools has resulted in some exciting findings, particularly in gut microbiome research. Recent examples of how metabolomics has informed analyses of the functional consequences of a changing microbiome in health and disease will be discussed. Examples include cardiometabolic diseases, yo-yo dieting, central obesity, asthma and response to immune checkpoint therapy.

Beebe K. et al., Understanding the Apothecaries Within: The Necessity of a Systematic Approach for Defining the Chemical Output of the Human Microbiome. Clinical and Translational Science (2014) 7:74-81

 


Date/Time Date(s) - Sep 18 2018 1:00 pm - 2:00 pm

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Location
UCC Lecture Theatre LG51 Cavanagh Pharmacy Building