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Finding the optimal probiotics for pregnant women & healthier babies

Dr Sally Cudmore, APC Microbiome Ireland, UCC; Mr Michael Creed, Minister for Agriculture, Food and the Marine and Dr Paul Cotter, Teagasc, APC Microbiome Ireland.

Minister for Agriculture, Food and the Marine, Michael Creed TD,has  launched Microbe Mom, a joint research investment of €3.4 million by Science Foundation Ireland through the SFI Spokes programme and leading Irish company Alimentary Health Group, led by the SFI Research Centre APC Microbiome Ireland.

Microbe Mom is new therapeutic research collaboration investigating:

  • the most likely methods of transfer of bifidobacteria strains from mother to baby,
  • the impact of the mother’s diet and health on her gut bacteria and what bacteria she transfers to her baby at birth,
  • the impact of specific probiotic supplements on the mother’s health.

Microbe Mom is a 4-way collaboration between:

Minister for Agriculture, Food and the Marine, Michael Creed TD, commented on MicrobeMom: “I am delighted to officially launch Microbe Mom, an important collaboration between academia and industry that will generate impactful health solutions for mothers and infants in Ireland. Optimising diet and the nature of food and supplements for pregnant women and babies is crucial to ensuring their health and wellbeing throughout their lives. In addition to helping us achieve this, Microbe Mom will also further solidify Cork’s reputation as a hub of excellent research.”

Welcoming the investment, Minister of State for Training, Skills, Innovation, Research and Development, John Halligan, TD, said, “I welcome the announcement of the Microbe Mom research project today, which will focus on improving the health of mothers and babies by looking at the diet of mothers and the transfer of bacteria at birth. The wellbeing of mothers and babies is very important to the Irish Government, and so it is great to see this significant joint-investment by the Government Agency, Science Foundation Ireland (SFI), and Irish company, Alimentary Health Group. This project will build on the long-standing partnership between the company and the SFI Research Centre ‘APC Microbiome Ireland’ in UCC, which in and of itself is a demonstration of the great heights that Irish science can achieve.”

Healthy development and maturation of a newborn baby is dependent on more than the genes of both parents; the microbes in the infant’s gut are also essential.  These microbes, collectively referred to as the microbiota, are acquired primarily by mother-to-baby transfer at birth, and subsequently from the environment. While much research to date has addressed the impact of the environment on the microbiota, the Microbe Mom research programme will focus on transfer of specific strains of bacteria from mother to baby, and in particular, the Bifidobacteria strains.

Bifidobacteria are the main bacteria that nature selects for the newborn gut and have been shown to play a key role in programming metabolism and the immune system. Indeed, exposure to the right microbes in this critical development window plays an important role in allergy and asthma risk as well as metabolic health in later life .  In Ireland 25% of women of reproductive age have increased weight with a BMI of greater than 30. Abnormal sugar control in pregnancy affects 5-15% of pregnancies.  Normal sugar control is important in pregnancy as high sugars are known to increase the risk of large for dates infants. Supplementation with probiotics has been shown to improve sugar control in men and women with type 2 diabetes  and prevent worsening insulin resistance in late pregnancy. Probiotics may have a role in normalising sugar in this group of women. However, each bacterial strain is unique and these studies will identify the optimum bifidobacteria for mother and baby health.

Bifidobacteria have received significant attention due to their proven contribution to human gut health and the use of specific strains as probiotics. Advances in DNA sequencing technology allow us to develop scientifically proven and clinically supported probiotic bifidobacteria, and investigate their transfer from mom to baby,” according to Microbe Mom project leader Dr Paul Cotter, Head of Department Food Biosciences in Teagasc and Principal Investigator at APC Microbiome Ireland.

Dr Eileen Murphy, Technical Director, Alimentary Health Group said “This research is key to understanding which bacteria make a key difference to baby. It’s also vital to understand how they can best be transferred to baby too e.g. should they be given to the mother during pregnancy or should we give them directly to baby? This knowledge will help us develop a range of probiotics with the precise qualities we need to optimise maternal and baby health”.

Professor Mark Ferguson, Director General of Science Foundation Ireland and Chief Scientific Adviser to the Government of Ireland said, “Science Foundation Ireland is delighted to support this new research programme, which brings together excellent researchers, clinicians and Irish SME Alimentary Health Group, to drive discovery in the transfer of bacteria from women to their babies.  This project demonstrates the important scientific advances and potential for new products that are being led by SFI Research Centres working with their partners in both academia and industry.”

Fergus Shanahan, Director of APC Microbiome Ireland added “this collaboration is further evidence of the wisdom of national research centres and APC Microbiome Ireland is delighted to be blending the expertise of the APC scientists with working such wonderful clinician-scientists at the National Maternity Hospital and bioprocessing experts at NIBRT”.

Pregnancy and early life present a unique time in the life course, where mother and baby health can be significantly improved. This innovative research programme holds considerable potential to improve mother’s health in pregnancy, in terms of sugars and blood lipids and to enhance baby’s health in the long-term by ensuring a healthy gut microbiome.  We are delighted to provide the clinical expertise for this national research collaboration.  The Microbe Mom research will contribute to our overall aim of enabling women to have the healthiest pregnancies and the healthiest babies they can” said Professor Fionnuala McAuliffe, Professor of Obstetrics & Gynaecology at University College Dublin & National Maternity Hospital, and Director of UCD Perinatal Research Centre.

MicrobeMom_Press release 23.10.2018