Niall P. Hyland APEX

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Niall P. Hyland

 

 

 

Career profile:

Employment & Education

2008 – present, Lecturer in Pharmacology and Faculty APC Microbiome Institute, University College Cork, Ireland.

2007 – 2008, Senior Postdoctoral Fellow, University College Cork, Ireland.

2004 – 2007, Postdoctoral Fellow, University of Calgary, Canada.

1998 – 1999, Visiting Research Fellow, Louisiana State University, USA.

2011 – 2012, PG Cert Teaching and Learning in Higher Education, University College Cork, Ireland.

2000 – 2004, PhD Pharmacology, King’s College London, UK.

1996 – 2000, BSc (Hons) Biomedical Sciences, University of Ulster, Northern Ireland.

HISTORY OF MENTORING AND SUPERVISION

Current Completed
Post-doctoral 1 1
PhD 3 1
MSc 1

 

INNOVATION/COMMERCIALISATION ACTIVITY

  • 2016 – Science Foundation Ireland Industry Fellowship (Host).
  • 2016 – Irish Research Council Enterprise Partnership Scheme (Academic Mentor).
  • Consultancy – Johnson & Johnson Consumer Inc. (current); Bayer Consumer Health (2016); and Janssen Johnson & Johnson (2015).

Since 2010 I have secured €39, 885 in Industry support for my research activities.

OTHER INFORMATION AS APPROPRIATE Principal scientific activities and responsibilities

My laboratory has most recently been investigating the interactions between the gut microbiome and host in the context of intestinal physiology and function. Currently funded projects are examining the effects of host- and microbial-derived metabolites on small intestinal physiology and their neuro-activity profile and the intestinal bioavailability and anti-inflammatory properties of a plant source, multi-mineral, from Lithothamnion red algae. Current collaborative projects are investigating microbial drug metabolism and the establishment of a ‘pharmacomicrobiomoics’ platform (School of Pharmacy and Department of Psychiatry and Neurobehavioural Science); the bladder microbiome (Department of Obstetrics and Gynaecology); and the temporal changes in the gut microbiome during colon carcinogenesis (School of Microbiology, School of Pharmacy and Department of Medicine).

Statement demonstrating accomplishments as an independent PI

I first obtained independent research support as a postdoctoral fellow at the University of Calgary from the Canadian Association of Gastroenterology and have since successfully obtained independent research funding from the Health Research Board, Science Foundation Ireland and the Irish Research Council. Career to date I have attracted research funding in excess of €600,000.

I have a record of independent publications from my time at Louisiana State University, King’s College London and the University of Calgary and in 2016 edited the book, The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota published by Elsevier/Academic Press with Prof. Catherine Stanton. In January 2017 I took up the position of Vice President – Meetings of the British Pharmacological Society and joined the Editorial Board of the British Journal of Pharmacology. I contribute to the activities of the American Gastroenterological Association Institute Council and European Society of Neurogastroenterology and Motility, and successfully bid to host the European Society’s ‘NeuroGASTRO’ meeting at UCC in 2017. In the context of contributions to the University community, I am a member of the Animal Experimentation Ethics Committee and of the newly established UCC Conferencing Office Directorate.

Key invited talks in 2016;

  • 49th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (Athens, Greece).
  • 22nd Society on NeuroImmune Pharmacology Meeting (Krakow, Poland).
  • NeuroImmunoPhysiology of the Gastrointestinal Tract Meeting (Banff, Canada).
  • XIV International Congress of Toxicology (Merida, Mexico).

Current and past research support

Current Duration Amount
SFI Industry Fellowship – Host 2016 €18,389
Irish Research Council EPS – Academic Mentor 2016-2018 €91,790
APC Microbiome Institute Innovation Platform

(2 PhD and 1 MSc/PhD funded postgraduates)

2015-2019 €348,000
Past
School of Medicine Translational Research Access

Programme (TRAP)

2014-2015 €9,000
Enterprise Ireland – Horizon 2020 Travel Grant 2015 €650
Health Research Board – Health Research Awards (PI) 2011-2014 €173,897
Canadian Association of Gastroenterology –

Research Initiative Award

2004-2007 CDN$165,000

 

Grant Reviewer 2015/2016

  • Fonds National de la Recherche (FNR; Luxembourg) – CORE scheme.
  • Royal Netherlands Academy of Arts and Sciences (KNAW).
  • European Research Council (ERC) – ERC Starting Grants.
  • National Science Centre Poland – HARMONIA funding scheme.

Contribution to External Organisations

  • Vice President – Meetings, British Pharmacological Society.
  • National Representative, European Society of Neurogastroenterology and Motility

Steering Committee.

  • Chair and Member of the Scientific Committee, Probiota 2017.
  • Councillor, Neurogastroenterology & Motility section of the American

Gastroenterological Association Institute Council.

  • Co-chair, British Pharmacological Society Systems and Integrative Pharmacology Affinity Group.

 

hindex 18; over 900 citations Total number Senior author
Primary Research Articles 23 13
Review Articles 7 6
Commentary / Letters 3 2
Book Chapters 1 1
Edited Books 1 NA

 

Zhdanov AV, Okkelman IA, Golubeva AV, Doerr B, Hyland NP, Melgar S, Shanahan F, Cryan JF, Papkovsky DB (2017) Quantitative analysis of mucosal oxygenation using ex vivo imaging of healthy and inflamed mammalian colon tissue. Cell Mol Life Sci, 74:141-151.

 

Buckley MM, O’Brien R, Devlin M, Creed AA, Rae MG, Hyland NP, Quigley EM, McKernan DP, O’Malley D (2016) Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague-Dawley rats. Exp Physiol, 101:1477-1491.

 

Golubeva AV, Crampton S, Desbonnet L, Edge D, O’Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O’Halloran KD, Dinan TG, O’Keeffe GW, Cryan JF (2015) Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood. Psychoneuroendocrinology, 60:58-74.

 

*Hyland NP, O’Mahony SM, O’Malley D, O’Mahony CM, Dinan TG, Cryan JF (2015)

Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction. Neurogastroenterol Motil, 27(1):105-13.

 

O’Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O’Toole PW, Dinan TG, Cryan JF (2014). Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats. Neuroscience, 277:885-901.

 

*Lomasney KW, Cryan JF, Hyland NP (2014) Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology. Am J Physiol Gastrointest Liver Physiol., 307(2):G241-7.

 

*Lomasney KW, Houston A, Shanahan F, Dinan TG, Cryan JF, Hyland NP (2014) Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon. Neurogastroenterol Motil., 26(6):887-90. Published as a Hot Topic

 

*Carroll SY, O’Mahony SM, Grenham S, Cryan JF, Hyland NP  (2013) Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain. PLoS One, 8(12):e84718.

 

O’Malley D, Liston M, Hyland NP, Dinan TG, Cryan JF (2011) Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an Interleukin-6-dependent mechanism. American journal of physiology. Gastrointestinal and liver physiology, 300(2):G241-52.

 

 

*Hyland NP,  Rybicka JM, Ho W, Pittman QJ, Macnaughton WK,  Sharkey KA. (2010) Adaptation of intestinal secretomotor function and nutrient absorption in response to diet- induced obesity. Neurogastroenterology and Motility, 22 (6):602-61. Published as a Hot Topic

 

Julio-Pieper M, Hyland NP, Bravo JA, Dinan TG, Cryan JF (2010) A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse. British Journal of Pharmacology, 160 (2):367-375.

 

Savignac HM, Hyland NP, Dinan TG, Cryan JF (2010) The effects of repeated social interaction stress on behavioural and physiological parameters in a stress-sensitive mouse strain. Behavioural brain research, 216 (2):576-84.

 

Pruteanu M, Hyland NP, Clarke DJ, Kiely B, Shanahan F (2010) Degradation of the extracellular matrix components by bacterial-derived metalloproteases: Implications for inflammatory bowel diseases. Inflammatory Bowel Diseases, 17(5):1189-200.

 

*Hyland NP, Chambers AP,  Keenan CM, Pittman QJ, Sharkey KA (2009) Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?. American journal of physiology. Gastrointestinal and liver physiology, 297 (5):G869-77.

 

*Hyland NP, Julio-Pieper M, O’Mahony SM, Bulmer DC, Lee K, Quigley EM, Dinan TG, Cryan JF (2009) A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?. Gut, 58 (7):1029-101.

 

McKernan DP, Nolan A, Brint EK, O’Mahony SM, Hyland NP, Cryan JF, Dinan TG (2009) Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome. PloS ONE, 4(12):e8226.

 

*Spencer SJ, Hyland NP, Sharkey KA, Pittman QJ (2007) Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-alpha. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 292 (1):R308-315. Joint first author.

 

*Hyland NP, Pittman QJ, Sharkey KA (2007) Peptide YY containing enteroendocrine cells and peripheral tissue sensitivity to PYY and PYY(3-36) are maintained in diet-induced obese and diet-resistant rats. Peptides, 28 (6):1185-1190.

 

*Lomax AE, O’Hara JR, Hyland NP, Mawe GM, Sharkey KA. (2006) Persistent alterations to enteric neural signalling in the colon following resolution of colitis. American journal of physiology. Gastrointestinal and liver physiology, 292 (2):G282-491. Joint first author.

 

*Hyland NP and Cox HM. (2005) The regulation of veratridine-stimulated electrogenic ion transport in mouse colon by neuropeptide Y (NPY), Y1 and Y2 receptors. British Journal of Pharmacology, 146 (5):712-722.

 

*Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM. (2003) Functional consequences of neuropeptide Y Y2 receptor knockout and Y2 antagonism in mouse and human colonic tissues. British Journal of Pharmacology, 139 (4):863-871.

 

McDermott CM, Abrahams TP, Partosoedarso E, Hyland N, Ekstrand J, Monroe M, Hornby PJ. (2001) Site of action of GABAB receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats. Gastroenterology, 120 (7):1749-1762.

 

*Hyland NP, Abrahams TP, Fuchs K, et al. (2001) Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets. Journal of Comparative Neurology, 430 (2):222-234.

 

Review Articles

Hyland NP, Cryan JF (2016) Microbe-host interactions: Influence of the gut microbiota on

the enteric nervous system. Dev Biol.,417(2):182-7.

 

Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci.,14;9:392.

 

Hyland NP, Quigley EM, Brint E (2014). Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions. World J Gastroenterol, 20(27):8859-66.

 

Lomasney KW, Hyland NP  (2013).The application of Ussing chambers for determining the impact of microbes and probiotics on intestinal ion transport. Can J Physiol Pharmacol,91(9):663-70.

 

Heuston S, Hyland NP (2012). Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders? Br J Pharmacol, 167(4):732-40.

 

O’Mahony SM, Hyland NP, Dinan TG, Cryan JF (2010) Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology, 214(1):71-88.

 

Book Chapters and Edited Books

The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota

Niall Hyland & Catherine Stanton (Ed.). (2016) The Gut-Brain Axis: Dietary, Probiotic, and

Prebiotic Interventions on the Microbiota Oxford, UK: Academic Press.

Hyland NP and Cox HM (2004). NPY-like peptides, Y receptors and gastrointestinal function In: Michel MC, ed. Handbook of experimental pharmacology: NPY and related peptides. Heidelberg: Springer.

Publications:

Please see http://publish.ucc.ie/researchprofiles/C007/nhyland

Contact details: Email: n.hyland@ucc.ie; Tel +353 21 4901267/1721