Oatmeal, healthy bugs and a happy heart
by Paul Ryan, previous APC PhD student, now studying medicine
APC Microbiome Institute scientists have confirmed that gut microbes play a role in heart health. We also demonstrated that we should consume porridge regularly to get the benefits of oat beta glucan for heart and gut health!
Our study, published in Microbiome, found that consumption of oat beta glucan not only lowered blood cholesterol in mice, it also helped keep body weight down and altered both the composition and functionality of the gut microbiota. The level of butyrate, a type of fatty acid produced by gut bacteria which has been previously shown to protect against diet-induced obesity in mice, was elevated in this study. Oat beta glucan also acted as a prebiotic, and increased bacteria in the gut which are being explored by others to treat obesity.
Plant sterol esters, which too were tested in this study, were found to be the most effective in lowering blood cholesterol and helping to avoid plaque build-up, but caused the greatest weight and adiposity gains and adversely affected the gut microbiota composition of the mice.
Cardiovascular disease is currently responsible for approximately 30% of deaths annually across the globe. Diet and exercise are known interventions to prevent or slow down the development of atherosclerosis but it has become evident that our gut bacteria also contribute.
In the study mice were fed a high fat diet together with either a food supplement or medication over a period of 24 weeks. The food supplements used in the study were plant sterol ester (the plant equivalent of cholesterol, currently added to some foods) and oat beta glucan (found in porridge). The drug used was Atorvastatin, one of the ‘statin’ group of drugs. The particular mice used are susceptible to the build-up of cholesterol in their arteries because they are apoE-/- deficient.
Atorvastatin and plant sterol esters are known to reduce levels of ’bad‘ cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of ’good‘ cholesterol (high-density lipoprotein, or HDL). They are used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. In this study, mice treated with Atorvastatin had similar physiology to the mice treated with oat beta glucan (reduced body weight and percentage body fat).
The takehome message is to take porridge regularly to reduce your risk of cardiovascular disease whilst also protecting your gut microbiota.
Paul M. Ryan, Lis E. London, Trent C. Bjorndahl, Rupasri Mandal, Kiera Murphy, Gerald F. Fitzgerald, Fergus Shanahan, R. Paul Ross. David S. Wishart, Noel M. Caplice and Catherine Stanton (2017) Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E-/- mice Microbiome DOI 10.1186/s40168-017-0246-x
PHOTO (left to right): Prof Noel Caplice, Professor of Cardiovascular Science, Director of the Centre for Research in Vascular Biology and investigator APC Microbiome Institute, UCC; Prof Catherine Stanton, leader of the research, APC Microbiome Institute and Teagasc Food Research Centre, Moorepark, Co. Cork and Dr Paul Ryan, APC Microbiome Institute, UCC. (Photographer: Cathal Noonan)