Research Title: IBD-ome: Unravelling the metabolic etiology of Inflammatory Bowel Disease (IBD) via lipidome, metabolome and microbiome multivariate analyses.
Project Background: Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation that leads to diminished quality of life and sometimes to severe disability. Despite considerable suffering the exact cause of IBD is unknown. Besides genetic factors, IBD is associated with reduced gut microbial diversity and metabolic extremes indicating a role for diet, life style, host and microbial metabolism. Biological samples from male and female IBD sufferers and healthy controls have been bio-banked for analysis across the metabolic spectra (BMI ranges). Microbial and other biochemical analysis have been performed.
Project Aims: IBD-ome aims to examine the metabolic etiology of IBD, through a series of state-of-the-art lipidomic and metabolomic analysis. Using predetermined microbiome data, bioinformatics multivariate analysis will interrogate these data. The outcome from IBD-ome will be metabolic and microbial discrimination of the various forms and stages of IBD from the same patient cohort across the BMI ranges.