Carina Carbia Sinde
Research Title: Binge & Bugs. Gut Microbiota, Neuropsychology and young Binge Drinkers (MicroB&B)
Project Summary: Binge drinking (BD) is a prevalent pattern of alcohol consumption among young people, which has been associated with neuroanatomical impairments and neuropsychological deficits, as well as increased risk of developing psychopathology and addiction. BD alters immune and stress responses, which appears to contribute to the neurocognitive difficulties and the neurobiology of drinking escalation. This inflammatory cascade could be compatible with alterations in the gut-brain axis. MicroB&B is aimed at determining new biomarkers of dysfunction and their neurocognitive correlates in young BDs. Following a psychoneuroimmunology perspective, we will investigate the association between alterations in gut microbiota and neuropsychological functioning in BDs. This interdisciplinary approach has a clear impact as early perturbations in the gut-brain axis could contribute to the development of future alcohol addiction or other psychiatric disorders later in life. MicroB&B will be developed at the APC Microbiome Ireland under the supervision of Prof. Ted Dinan and Prof. John Cryan and will enable the continuation of previous studies on animal models of alcohol use and microbiota-alterations completed at the APC.