Brian McSharry

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Brian McSharry – APC Faculty

Brian McSharry graduated with a BSc in Biotechnology from the National University of Ireland, Galway before pursuing a PhD in Prof Gavin Wilkinson’s laboratory in Cardiff University studying human cytomegalovirus infection.  Following subsequent postdoctoral work at NUIG, Cardiff University and Trinity College Dublin, Brian moved to the University of Sydney in 2011 where he continued his studies of human herpesvirus infections. Brian returned from Australia in 2019 to take up a lecturer position in the School of Microbiology at University College Cork. His research interests are focussed on the molecular mechanisms encoded by large DNA viruses, in particular herpesviruses, to regulate host response pathways.  Primary herpesvirus infection is followed by lifelong persistence maintenance. To facilitate this persistence these viruses have evolved a range of mechanisms to control/disarm host immunity.  In particular, his studies have focussed on regulation of Natural Killer (NK) cells by viruses through control of NK cell ligand expression, in addition, to direct infection of these immune effectors. Brian is also interested in how the interferon response controls viral infection through the action of specific interferon stimulated genes.  These studies have defined novel viral encoded immunoregulatory strategies as well as providing insights into host immune pathways.