Host–Microbe Dialogue
The APC’s Host-Microbe Dialogue theme explores the network of signalling interactions among the microbiota, host immune-inflammatory responses and metabolism and the impact of diet on each component of this triad. The gut microbiota influences human health and susceptibility to most common diseases, including immune-allergic, colon cancer and various metabolic diseases, such as obesity-related disorders, diabetes and cardiovascular disease. Each of these chronic disorders has an immune or inflammatory component, and indeed, the aging process itself, is associated with increases in low-grade inflammation (inflammageing). This low-grade inflammation, and the diseases associated with it, is a significant healthcare burden in developed countries, and represents a multi-billion € opportunity for companies in the food, pharmaceutical and diagnostic sectors.
The APC has built a global reputation in inflammatory diseases, particularly in functional gastrointestinal conditions, inflammatory bowel disease (IBD) and in inflammation of the aged. The challenge now is to develop outputs, such as new robust microbial and other biomarkers of disease risk and to manipulate disease risk by targeting the microbiota using designer foods and/or pharmabiotics. This is a strategically important area both in the context of the ageing population and evolving economic and public health policies.
 | Sinead C. Corr Title: Dr. Position: APC Faculty Department: Moyne Institute of Preventative Medicine; Trinity College Dublin Email: corrsc@tcd.ie Phone: +353 1 8961195 |
 | Noel Caplice Title: Professor Position: APC Faculty Department: Medicine, Centre Vascular Biology / CUH Email: n.caplice@ucc.ie Phone: 4901329 |
 | Marcus Claesson Title: Dr. Position: Funded Investigator Department: Microbiology Email: m.claesson@ucc.ie Phone: 4901390 |
 | David Clarke Title: Dr Position: Funded Investigator Department: Microbiology Email: David.clarke@ucc.ie Phone: 4903624 |
 | Cormac Gahan Title: Dr Position: Funded Investigator Department: Microbiology Email: c.gahan@ucc.ie Phone: 4901363 |
| Liam Fanning Title: Dr Position: Funded Investigator Department: Medicine Email: l.fanning@ucc.ie Phone: | |
 | Liam O’Mahony Title: Professor Position: Funded Investigator Department: Microbiology Email: liam.omahony@ucc.ie Phone: 4901316 |
 | Susan Joyce Title: Dr Position: APC Faculty Department: School of Biochemistry & Cell Biology Email: s.joyce@ucc.ie Phone: 4901723/1343 |
 | John MacSharry Title: Dr Position: APC Faculty Department: Medicine Email: j.macsharry@ucc.ie Phone: 4902642 |
 | Ken Nally Title: Dr Position: Funded Investigator Department: Biochemistry Email: k.nally@ucc.ie Phone: 4901302 |
 | Mark Tangney Title: Dr Position: APC Faculty Department: Cancer Research @ UCC Email: m.tangney@ucc.ie Phone: 4901372 |